Impaired gamma interferon response to Mycobacterium vaccae antigens in patients with cavitary pulmonary tuberculosis.

نویسندگان

  • Elisabeth Rodríguez-Güell
  • Gemma Agustí
  • Mercè Corominas
  • Marina Luquin
  • Esther Julián
چکیده

The ability of tuberculosis patients to recognize Mycobacterium vaccae-specific antigens before starting chemotherapy and according to disease severity was analyzed. We report that the M. vaccae cell wall skeleton fraction triggers more enhanced cytokine production than the whole bacterium. Moreover, a tendency was observed for a lower gamma interferon/interleukin-10 ratio in patients with cavitary disease induced by M. vaccae antigens.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 15 9  شماره 

صفحات  -

تاریخ انتشار 2008